25 February 2025
Dr Luke Walker Pediatric Oncology Fellow, JHH
Dr Noemi Fuentes Bolanos Pediatric Oncologist and Clinical Geneticist Kids Cancer Centre, Sydney Children's Hospital
Associate Professor Kathy Tucker Clinical Cancer Geneticist Hereditary Cancer Centre, Prince of Wales Hospital
Treatment of adrenocortical carcinoma
Clinical presentation and evaluation of adrenocortical tumors
The European Society for Pediatric Onocology Adrenocortical tumors in children and adolescents V.8, (nd)
St. Jude Children's Research Hospital Adrenocortical Tumor Treatment
Lee, M., Lui, A.C.Y., Chan, J.C.K. et al. Revealing parental mosaicism: the hidden answer to the recurrence of apparent de novo variants. Hum Genomics 17, 91 (2023). https://doi.org/10.1186/s40246-023-00535-y
Achatz, Maria Isabel, and Gerard P Zambetti. The Inherited p53 Mutation in the Brazilian Population. old Spring Harbor perspectives in medicine vol. 6,12 a026195. 1 Dec. 2016, doi:10.1101/cshperspect.a026195
Li-Fraumeni Syndrome Association Criteria for LFS
Wang, H., Guo, M., Wei, H. et al.Targeting p53 pathways: mechanisms, structures and advances in therapy. Sig Transduct Target Ther 8, 92 (2023). https://doi.org/10.1038/s41392-023-01347-1
EviQ Facts for people and families with a faulty TP53 gene (Li-Fraumeni syndrome)
Colgan JN, Fuentes-Bolanos NA, Barbaric D, Dalla-Pozza L, Mitchell R, Samarasinghe S, et al.Scylla and Charybdis: Unpalatable choices in managing hypodiploid acute lymphoblastic leukemia. EJC Paediatric Oncology. 2023;2:100133.
Fortuno, Cristina et al.Cancer Risks Associated With TP53 Pathogenic Variants: Maximum Likelihood Analysis of Extended Pedigrees for Diagnosis of First Cancers Beyond the Li-Fraumeni Syndrome Spectrum. JCO precision oncology vol. 8 (2024): e2300453. doi:10.1200/PO.23.00453
FVillani, Anita et al.Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study.The Lancet. Oncology vol. 17,9 (2016): 1295-305. doi:10.1016/S1470-2045(16)30249-2
Back