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2022

Other years  2021 2020

2022 Program

12.30 pm – 1.30 pm Thursdays. JHH Large Lecture Theatre or via Zoom
Zoom link https://uonewcastle.zoom.us/j/85147051183

Palliative care: An essential piece in the acute care puzzle
Presented 22 November 2022
	Ms Nicole Cairns - Nurse Practitioner, JHH Palliative Care Ms Therese Hayden - CNC, JHH Palliatve Care Dr Rachel Hughes - Director, CMN Palliative Care		Screencast
			mp4
	Palliative Care Hospital Health Pathway
	Benefits, services, and models of subspecialty palliative care
	Hawley PH. The bow tie model of 21st century palliative care. J Pain Symptom Manage. 2014 Jan;47(1):e2-5. PubMed PMID: 24321509. Epub 20131208. eng.
	Clark K, Byrne PG, Hunt J, Brown L, Rowett D, Watts G, et al. Pharmacovigilance in Hospice/Palliative Care: De-Prescribing Combination Controlled Release Oxycodone-Naloxone. J Palliat Med. 2020 May;23(5):656-61. PubMed PMID: 31904310. Epub 20200103. eng.
	Ong CK, Forbes D. Embracing Cicely Saunders's concept of total pain. BMJ. 2005 Sep 10;331(7516):576. PubMed PMID: 16150775. PMCID: PMC1200625. eng.

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Between a rock and hard places

	Dr William Yu Advanced Trainee, Endocrinology John Hunter Hospital		Screencast
			mp4
	Nutritional considerations in type 2 diabetes mellitus

What is sarcoidosis? Three cases and many questions

	Dr Theo de Malmanche Staff Specialist, Immunology & Rheumatology NSW Health Pathology		Screencast
			mp4
	Gastrointestinal, hepatic, pancreatic, and peritoneal sarcoidosis
	Clinical manifestations and diagnosis of cardiac sarcoidosis
	Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51. PubMed PMID: 32293205. PMCID: PMC7159433. eng.
	Nordenswan HK, Pöyhönen P, Lehtonen J, Ekström K, Uusitalo V, Niemelä M, et al. Incidence of Sudden Cardiac Death and Life-Threatening Arrhythmias in Clinically Manifest Cardiac Sarcoidosis With and Without Current Indications for an Implantable Cardioverter Defibrillator. Circulation. 2022 Sep 27;146(13):964-75. PubMed PMID: 36000392. PMCID: PMC9508990. Epub 20220824. eng.

Aspergillus: Just another Fun-Guy!

Aspergillus: Just another Fun-Guy!
Presented 27 October 2022
	Dr Brian Chong Staff Specialist, Immunology & Infectious Diseases John Hunter Hospital		Screencast
			mp4
	Treatment and prevention of invasive aspergillosis

Dermatomyositis across the ages

	Dr Olav Tvedten Rheumatology Advanced Trainee, John Hunter Hospital Dr Jeffrey Chaitow Paediatric Rheumatologist, Children's Hospital Westmead		Screencast
			mp4
	Overview of and approach to the idiopathic inflammatory myopathies
	Khadilkar SV, Dhamne MC. What is New in Idiopathic Inflammatory Myopathies: Mechanisms and Therapies. Ann Indian Acad Neurol. 2020;23(4):458-67.
	Bellutti Enders F, Bader-Meunier B, Baildam E, Constantin T, Dolezalova P, Feldman BM, et al. Consensus-based recommendations for the management of juvenile dermatomyositis. Ann Rheum Dis. 2017 Feb;76(2):329-40. PubMed PMID: 27515057. PMCID: PMC5284351. Epub 20160811. eng.
	Leclair V, Lundberg IE. New Myositis Classification Criteria-What We Have Learned Since Bohan and Peter. Curr Rheumatol Rep. 2018 Mar 17;20(4):18. PubMed PMID: 29550929. PMCID: PMC5857275. Epub 20180317. eng.
	Aggarwal R, Charles-Schoeman C, Schessl J, Bata-Csörgo Z, Dimachkie MM, Griger Z, et al. Trial of Intravenous Immune Globulin in Dermatomyositis. N Engl J Med. 2022 Oct 6;387(14):1264-78. PubMed PMID: 36198179. eng.

Lifting our game at JHH for somatic symptoms and related disorders

Updates from JHH Somatic Symptoms Disorders Collaboration
	Dr Liz Pepper Co-Director and Senior Staff Specialist, Neurology Dr Jessica Davis, PhD (Clin Psy) Senior Clinical Psychologist, Allied Health and Rehabilitation Services Gold Coast Hospital and Health Service Dr Matt Elton Consultant Liaison Psychiatrist		Screencast
			mp4
	Would you like to review Dr Matt Elton's paper? Email Dr Elton for access
	American Psychiatric Association. Functional Neurological Symptom Disorder (Conversion Disorder) DSM-5
	American Psychiatric Association. Somatic symptom disorder DSM-5
	Stieler M, Pockney P, Campbell C, Thirugnanasundralingam V, Gan L, Spittal M, et al. Using the Patient Health Questionnaire to estimate prevalence and gender differences of somatic symptoms and psychological co-morbidity in a secondary inpatient population with abdominal pain. Aust N Z J Psychiatry. 2022 Aug;56(8):994-1005. PubMed PMID: 34482758. Epub 20210904. eng.
	Stieler M, Pockney P, Campbell C, Thirugnanasundralingam V, Gan L, Spittal MJ, et al. Somatic symptom severity association with healthcare utilization and costs in surgical inpatients with an episode of abdominal pain. BJS Open. 2022 Jul 7;6(4). PubMed PMID: 35796068. PMCID: PMC9260183. eng.
	SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. Br J Surg. 2021 Sep 27;108(9):1056-63. PubMed PMID: 33761533. PMCID: PMC7995808. eng.
	Kanaan RAA, Craig TKJ. Conversion disorder and the trouble with trauma. Psychological medicine. 2019 Jul;49(10):1585-8. PubMed PMID: 31044689. Epub 20190502. eng.
	Howman M, Walters K, Rosenthal J, Ajjawi R, Buszewicz M. "You kind of want to fix it don't you?" Exploring general practice trainees' experiences of managing patients with medically unexplained symptoms. BMC Med Educ. 2016 Jan 25;16:27. PubMed PMID: 26810389. PMCID: PMC4727318. Epub 20160125. eng.
	Yon K, Nettleton S, Walters K, Lamahewa K, Buszewicz M. Junior doctors' experiences of managing patients with medically unexplained symptoms: a qualitative study. BMJ Open. 2015 Dec 1;5(12):e009593. PubMed PMID: 26628528. PMCID: PMC4679901. Epub 20151201. eng.
	Lehmann M, Pohontsch NJ, Zimmermann T, Scherer M, Löwe B. Diagnostic and treatment barriers to persistent somatic symptoms in primary care - representative survey with physicians. BMC Fam Pract. 2021 Apr 1;22(1):60. PubMed PMID: 33794776. PMCID: PMC8017612. Epub 20210401. eng.
Somatisation disorders forum (click here to access forum page or on links below for individual presentations)
Presented 15 October 2021
	Dr Mel Stieler, Paediatric Surgery Registrar Introduction to Somatoform and Functional Disorders Dr Clair Spry, Emergency Medicine Fellow Somatic symptoms disorders in ED Dr Liz Pepper, Co-Director and Senior Staff Specialist, Neurology Functional Neurological Disorder Dr Gali Lawrence, Clinical Neuropsychologist When the pain is not in your head but the solution is not in your body Dr Matt Elton, Liaison Psychiatry Consultant JHH Consultation Liaison Psychiatry & HETI Fellowship Ms Sharon Bowen, District Clinical Coding Manager Clinical coding Led by Professor Chris Levi, Director, John Hunter Health and Innovation Precinct General Discussion

Lung cancer: Past, present and future

Chemotherapy, targeted therapy and immunotherapy
	Dr Hiren Mandaliya Medical Oncologist Calvary Mater Hospital		Screencast
			mp4
	Overview of the initial evaluation, diagnosis, and staging of patients with suspected lung cancer

Pregnancy, an exciting time... For the immune system

	Dr Theo de Malmanche Director, Immunology John Hunter Hospital		Screencast
			mp4
	Immunology of the maternal-fetal interface
	Diagnostic approach to suspected TTP, HUS, or other thrombotic microangiopathy (TMA)

Gut instincts: Cirrhosis related Parkinsonism

	Dr Dan Oliver Advanced Trainee, General Medicine John Hunter Hospital		Screencast
			mp4
	Apetauerova D, Patel PA, Burns JD, Lerner DP. Movement Disorder Emergencies. Neurol Clin. 2021 May;39(2):615-30. PubMed PMID: 33896535. Epub 20210331. eng.

A might catch from the Peel: 'Nick'

	Dr Pat Oakley - Senior Physician, ICCAPP Mr Matt Crawford - CNC, ICCAPP Mr Damion Brown - Acting CEO, Tamworth Aboriginal Medicine Service Dr Costa Karihaloo - Obesity and General Surgeon		Screencast
			mp4
	Aly A, Talbot ML, Brown WA. Bariatric surgery: a call for greater access to coordinated surgical and specialist care in the public health system. Med J Aust. 2022;217(5):228-31.

DAMA drama: Discharge against medical advice in the substance using patient

	Dr Stacey Weedon Staff Specialist, Drug & Alcohol Clinical Services Dr Adrian Dunlop Director & Snr Staff Specialist, Drug & Alcohol Clinical Services		Screencast
			mp4
	Holmes EG, Cooley BS, Fleisch SB, Rosenstein DL. Against Medical Advice Discharge: A Narrative Review and Recommendations for a Systematic Approach. Am J Med. 2021 Jun;134(6):721-6. PubMed PMID: 33610522. Epub 20210218. eng.

New strategies for an old disease

	Dr Simon Graffen Advanced Trainee, Respiratory and Sleep Medicine Dr Vineeth George Stafff Specialist, Respiratory and Sleep Medicine		Screencast
			mp4
	Hassan M, Cargill T, Harriss E, Asciak R, Mercer RM, Bedawi EO, et al. The microbiology of pleural infection in adults: a systematic review. Eur Respir J. 2019 Sep;54(3). PubMed PMID: 31248959. Epub 20191001. eng.
	Kanellakis NI, Wrightson JM, Gerry S, Ilott N, Corcoran JP, Bedawi EO, et al. The bacteriology of pleural infection (TORPIDS): an exploratory metagenomics analysis through next generation sequencing. Lancet Microbe. 2022 Apr;3(4):e294-e302. PubMed PMID: 35544066. PMCID: PMC8967721. Epub 20220311. eng.
	Dyrhovden R, Nygaard RM, Patel R, Ulvestad E, Kommedal Ø. The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study. Clin Microbiol Infect. 2019 Aug;25(8):981-6. PubMed PMID: 30580031. Epub 20181221. eng.
	Corcoran JP, Psallidas I, Gerry S, Piccolo F, Koegelenberg CF, Saba T, et al. Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study. Eur Respir J. 2020 Nov;56(5). PubMed PMID: 32675200. Epub 20201126. eng.
	Rahman NM, Maskell NA, West A, Teoh R, Arnold A, Mackinlay C, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011 Aug 11;365(6):518-26. PubMed PMID: 21830966. eng.
	Popowicz ND, Piccolo F, Yap E, Wong C, Brockway B, Smith NA, et al. Long-term follow-up after intrapleural tPA/DNase therapy for pleural infection. Respirology. 2021 Apr;26(4):388-91. PubMed PMID: 33590570. Epub 20210215. eng.
	Dean NC, Griffith PP, Sorensen JS, McCauley L, Jones BE, Lee YC. Pleural Effusions at First ED Encounter Predict Worse Clinical Outcomes in Patients With Pneumonia. Chest. 2016 Jun;149(6):1509-15. PubMed PMID: 26836918. PMCID: PMC6026265. Epub 20160116. eng.

The perils of gardens and pets

	Dr Holly Jordan Advanced Trainee, Infectious Diseases Dr Rose Haywood Advanced Trainee, Microbiology & Infectious Diseases		Screencast
			mp4
	Microbiology, epidemiology, clinical manifestations, and diagnosis of cat scratch disease
	Central nervous system infections due to dematiaceous fungi (cerebral phaeohyphomycosis)
	de Camargo RA, Sommer Bitencourt M, Meneghetti JC, Soares J, Gonçalves LFT, Buchpiguel CA, et al. The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis. Clin Infect Dis. 2020 Feb 3;70(4):583-94. PubMed PMID: 30949690. Epub 2019/04/06. eng.
	Fournier PE, Thuny F, Richet H, Lepidi H, Casalta JP, Arzouni JP, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010 Jul 15;51(2):131-40. PubMed PMID: 20540619. Epub 2010/06/15. eng.
	Rantala M, Attia S, Koukila-Kähkölä P, de Hoog S, Anttila M, Katila T. Cladophialophora bantiana as an Emerging Pathogen in Animals: Case Report of Equine Endometritis and Review of the Literature. J Clin Microbiol. 2015 Sep;53(9):3047-53. PubMed PMID: 26085616. PMCID: PMC4540934. Epub 2015/06/19. eng.
	Kantarcioglu AS, Guarro J, De Hoog S, Apaydin H, Kiraz N. An updated comprehensive systematic review of Cladophialophora bantiana and analysis of epidemiology, clinical characteristics, and outcome of cerebral cases. Med Mycol. 2017 Aug 1;55(6):579-604. PubMed PMID: 28007938. Epub 2016/12/23. eng.
	Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi. Clin Microbiol Infect. 2014 Apr;20 Suppl 3:47-75. PubMed PMID: 24483780. Epub 2014/02/04. eng.

Pigs can fly

	Dr Adrienne Cohen Nephrology and Transplantation John Hunter Hospital		Screencast
			mp4
	Levy MF. Animal organs for human transplantation: how close are we? Proc (Bayl Univ Med Cent). 2000 Jan;13(1):3-6. PubMed PMID: 16389317. PMCID: PMC1312205. eng.
	Porrett PM, Orandi BJ, Kumar V, Houp J, Anderson D, Cozette Killian A, et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. Am J Transplant. 2022 Apr;22(4):1037-53. PubMed PMID: 35049121. Epub 20220120. eng.
	Montgomery RA, Stern JM, Lonze BE, Tatapudi VS, Mangiola M, Wu M, et al. Results of Two Cases of Pig-to-Human Kidney Xenotransplantation. N Engl J Med. 2022 May 19;386(20):1889-98. PubMed PMID: 35584156. eng.

The kidney heart love affair goes on

	Dr Steve May Nephrologist Tamworth Hospital		Screencast
			mp4
	Assessment of kidney function
	Moledina DG, Parikh CR. Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine. Semin Nephrol. 2018 Jan;38(1):3-11. PubMed PMID: 29291759. PMCID: PMC5753429. eng.
	Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021 Nov 4;385(19):1737-49. PubMed PMID: 34554658. PMCID: PMC8822996. Epub 2021/09/24. eng.
	Liu C, Mor MK, Palevsky PM, Kaufman JS, Thiessen Philbrook H, Weisbord SD, et al. Postangiography Increases in Serum Creatinine and Biomarkers of Injury and Repair. Clin J Am Soc Nephrol. 2020 Sep 7;15(9):1240-50. PubMed PMID: 32839195. PMCID: PMC7480551. Epub 20200824. eng.
	Brodsky SV, Satoskar A, Chen J, Nadasdy G, Eagen JW, Hamirani M, et al. Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases. Am J Kidney Dis. 2009 Dec;54(6):1121-6. PubMed PMID: 19577348. Epub 20090704. eng.

Spots the diagnosis: A rare complication of sepsis

	Dr Katie Richards Basic Physician Trainee, Intensive Care John Hunter Hospital		Screencast
			mp4
	Evaluation and management of disseminated intravascular coagulation (DIC) in adults
	Adelborg K, Larsen JB, Hvas AM. Disseminated intravascular coagulation: epidemiology, biomarkers, and management. Br J Haematol. 2021 Mar;192(5):803-18. PubMed PMID: 33555051. Epub 2021/02/09. eng.
	Contou D, Urbina T, de Prost N. Understanding purpura fulminans in adult patients. Intensive Care Med. 2022 Jan;48(1):106-10. PubMed PMID: 34846563. Epub 2021/12/01. eng.
	Contou D, Canoui-Poitrine F, Coudroy R, Préau S, Cour M, Barbier F, et al. Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study. Clin Infect Dis. 2019 Jul 2;69(2):332-40. PubMed PMID: 30335142. Epub 2018/10/20. eng.
	Iba T, Watanabe E, Umemura Y, Wada T, Hayashida K, Kushimoto S, et al. Sepsis-associated disseminated intravascular coagulation and its differential diagnoses. Journal of intensive care. 2019;7:32. PubMed PMID: 31139417. PMCID: PMC6528221. Epub 2019/05/30. eng.

Owning my failures: Two cautionary angioedema failures

	Dr Theo de Malmanche Immunologist John Hunter Hospital		Screencast
			mp4
	An overview of angioedema: Clinical features, diagnosis, and management
	An overview of angioedema: Pathogenesis and causes
	Isono M, Kokado M, Kato K. Why does it take so long for rare disease patients to get an accurate diagnosis?-A qualitative investigation of patient experiences of hereditary angioedema. PLoS One. 2022;17(3):e0265847. PubMed PMID: 35303740. PMCID: PMC8932585. Epub 20220318. eng.
	Paratz ED, Zhao J, Sherwen AK, Scarlato RM, MacIsaac AI. Is an Abnormal ECG Just the Tip of the ICE-berg? Examining the Utility of Electrocardiography in Detecting Methamphetamine-Induced Cardiac Pathology. Heart Lung Circ. 2017 Jul;26(7):684-9. PubMed PMID: 28110851. Epub 20161209. eng.
	Schürer S, Klingel K, Sandri M, Majunke N, Besler C, Kandolf R, et al. Clinical Characteristics, Histopathological Features, and Clinical Outcome of Methamphetamine-Associated Cardiomyopathy. JACC Heart Fail. 2017 Jun;5(6):435-45. PubMed PMID: 28571597. eng.

To BPPV or not to BPPV: Suffering the slings and arrows of outrageous management

	Dr Tom Wellings Neurologist John Hunter Hospital		Screencast
			mp4
	Benign paroxysmal positional vertigo
	Newman-Toker DE, Cannon LM, Stofferahn ME, Rothman RE, Hsieh YH, Zee DS. Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. Mayo Clin Proc. 2007 Nov;82(11):1329-40. PubMed PMID: 17976352. eng.
	Neely P, Patel H, Wellings T. Benign paroxysmal positional vertigo in the emergency department: An observational study of an Australian regional hospital's acute clinical practice. Emerg Med Australas. 2021 Dec;33(6):1082-7. PubMed PMID: 34092036. Epub 2021/06/07. eng.

RACP - Time for self-reflection and realignment?

	Professor Jennifer Martin RACP President-elect and CPAC Committee Chair Mr Peter McIntyre RACP CEO		Slides

Dual genetic diagnoses: Underappreciated 'double trouble"

	Dr Himanshu Goel Staff Specialist, Clinical Genetics		Screencast
			mp4
	Pseudoxanthoma elasticum
	Posey JE, Harel T, Liu P, Rosenfeld JA, James RA, Coban Akdemir ZH, et al. Resolution of Disease Phenotypes Resulting from Multilocus Genomic Variation. N Engl J Med. 2017 Jan 5;376(1):21-31. PubMed PMID: 27959697. PMCID: PMC5335876. Epub 20161207. eng.
	Liu L, Sun L, Chen Y, Wang M, Yu C, Huang Y, et al. Delineation of dual molecular diagnosis in patients with skeletal deformity. Orphanet J Rare Dis. 2022 Mar 28;17(1):139. PubMed PMID: 35346302. PMCID: PMC8962553. Epub 20220328. eng.
	Farwell KD, Shahmirzadi L, El-Khechen D, Powis Z, Chao EC, Tippin Davis B, et al. Enhanced utility of family-centered diagnostic exome sequencing with inheritance model-based analysis: results from 500 unselected families with undiagnosed genetic conditions. Genet Med. 2015 Jul;17(7):578-86. PubMed PMID: 25356970. Epub 2014/10/31. eng.
	Yang Y, Muzny DM, Reid JG, Bainbridge MN, Willis A, Ward PA, et al. Clinical whole-exome sequencing for the diagnosis of mendelian disorders. N Engl J Med. 2013 Oct 17;369(16):1502-11. PubMed PMID: 24088041. PMCID: PMC4211433. Epub 2013/10/04. eng.
	Smith ED, Blanco K, Sajan SA, Hunter JM, Shinde DN, Wayburn B, et al. A retrospective review of multiple findings in diagnostic exome sequencing: half are distinct and half are overlapping diagnoses. Genet Med. 2019 Oct;21(10):2199-207. PubMed PMID: 30894705. PMCID: PMC6774997. Epub 2019/03/22. eng.
	Hiz Kurul S, Oktay Y, Töpf A, Szabó NZ, Güngör S, Yaramis A, et al. High diagnostic rate of trio exome sequencing in consanguineous families with neurogenetic diseases. Brain. 2022 May 24;145(4):1507-18. PubMed PMID: 34791078. PMCID: PMC9128813. Epub 2021/11/19. eng.

Clearing up the confusion about confusion management

	Case presentation Dr Jo-Anne Ponce - Geriatrics Advanced Trainee Delirium Dr Karolina Kanczuga-Byszewski - Geriatrics Advanced Trainee HAC Delirium, Delirium and Dementia: JHH Data Leanne Pike - Dementia and Delirium CNC Code Black Quicklist and delirium management Cognitive screening in older patients undergoing elective surgery Dr Karolina Kanczuga-Byszewski - Geriatrics Advanced Trainee Slides by Dr Clarissa Sagi		Screencast
			mp4
	Nair BKR, editor. Geriatric Medicine : A Problem-Based Approach. Singapore: Springer Singapore Pte. Limited; 2017.
	Delirium and acute confusional states: Prevention, treatment, and prognosis
	Comprehensive Care - Minimising Harm
	Delirium Clinical Care Standard
	NSW Health Policy Directive, Seclusion and Restraint in NSW Health Settings, PD2020_004
	Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed., American Psychiatric Association, 2013. DSM-V, doi-org.db29.linccweb.org/10.1176/ appi.
	Gibb K, Seeley A, Quinn T, Siddiqi N, Shenkin S, Rockwood K, et al. The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study. Age Ageing. 2020 Apr 27;49(3):352-60. PubMed PMID: 32239173. PMCID: PMC7187871. eng.
	Wilson JE, Mart MF, Cunningham C, Shehabi Y, Girard TD, MacLullich AMJ, et al. Delirium. Nat Rev Dis Primers. 2020 Nov 12;6(1):90. PubMed PMID: 33184265. PMCID: PMC9012267. Epub 20201112. eng.
	Shenkin SD, Fox C, Godfrey M, Siddiqi N, Goodacre S, Young J, et al. Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method. BMC Med. 2019 Jul 24;17(1):138. PubMed PMID: 31337404. PMCID: PMC6651960. Epub 20190724. eng.
	Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing. 2006 Jul;35(4):350-64. PubMed PMID: 16648149. Epub 20060428. eng.
	McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med. 2002 Feb 25;162(4):457-63. PubMed PMID: 11863480. eng.
	Jackson TA, MacLullich AM, Gladman JR, Lord JM, Sheehan B. Undiagnosed long-term cognitive impairment in acutely hospitalised older medical patients with delirium: a prospective cohort study. Age Ageing. 2016 Jul;45(4):493-9. PubMed PMID: 27076525. Epub 20160413. eng.
	Hshieh TT, Yang T, Gartaganis SL, Yue J, Inouye SK. Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness. Am J Geriatr Psychiatry. 2018 Oct;26(10):1015-33. PubMed PMID: 30076080. PMCID: PMC6362826. Epub 20180626. eng.
	Mudge AM, McRae P, Banks M, Blackberry I, Barrimore S, Endacott J, et al. Effect of a Ward-Based Program on Hospital-Associated Complications and Length of Stay for Older Inpatients: The Cluster Randomized CHERISH Trial. JAMA Intern Med. 2022 Mar 1;182(3):274-82. PubMed PMID: 35006265. PMCID: PMC8749692. eng.
	Herling SF, Greve IE, Vasilevskis EE, Egerod I, Bekker Mortensen C, Møller AM, et al. Interventions for preventing intensive care unit delirium in adults. Cochrane Database Syst Rev. 2018 Nov 23;11(11):Cd009783. PubMed PMID: 30484283. PMCID: PMC6373634. Epub 20181123. eng.
	Zayed Y, Barbarawi M, Kheiri B, Banifadel M, Haykal T, Chahine A, et al. Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. J Crit Care. 2019 Apr;50:280-6. PubMed PMID: 30665181. Epub 20190112. eng.
	Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR. Melatonin--a pleiotropic, orchestrating regulator molecule. Prog Neurobiol. 2011 Mar;93(3):350-84. PubMed PMID: 21193011. Epub 20101228. eng.

Substituting the world's salt supply

	Professor Bruce Neal Executive Director The George Institute for Global Health		Screencast
			mp4
	Salt intake, salt restriction, and primary (essential) hypertension
	Oliver WJ, Cohen EL, Neel JV. Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture. Circulation. 1975 Jul;52(1):146-51. PubMed PMID: 1132118. eng.
	Mente A, O'Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014 Aug 14;371(7):601-11. PubMed PMID: 25119606. eng.
	He FJ, Ma Y, Campbell NRC, MacGregor GA, Cogswell ME, Cook NR. Formulas to Estimate Dietary Sodium Intake From Spot Urine Alter Sodium-Mortality Relationship. Hypertension. 2019 Sep;74(3):572-80. PubMed PMID: 31352828. Epub 20190729. eng.
	Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell RE, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014 Aug 14;371(7):624-34. PubMed PMID: 25119608. eng.
	Vinceti M, Filippini T, Crippa A, de Sesmaisons A, Wise LA, Orsini N. Meta-Analysis of Potassium Intake and the Risk of Stroke. J Am Heart Assoc. 2016 Oct 6;5(10). PubMed PMID: 27792643. PMCID: PMC5121516. Epub 20161006. eng.
	Neal B, Tian M, Li N, Elliott P, Yan LL, Labarthe DR, et al. Rationale, design, and baseline characteristics of the Salt Substitute and Stroke Study (SSaSS)-A large-scale cluster randomized controlled trial. Am Heart J. 2017 Jun;188:109-17. PubMed PMID: 28577665. Epub 20170314. eng.
	Marklund M, Singh G, Greer R, Cudhea F, Matsushita K, Micha R, et al. Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study. BMJ. 2020 Apr 22;369:m824. PubMed PMID: 32321724. PMCID: PMC7190075. Epub 20200422. eng.
	Bhat S, Marklund M, Henry ME, Appel LJ, Croft KD, Neal B, et al. A Systematic Review of the Sources of Dietary Salt Around the World. Adv Nutr. 2020 May 1;11(3):677-86. PubMed PMID: 31904809. PMCID: PMC7231587. eng.

Capacity to assess capacity

	Dr Matt Elton - Consultant Liaison Psychiatrist Dr Priscilla Mantovani - Consultant Liaison Psychiatrist Dr Gali Lawrence - Clinical Psychologist Clinical Associate Professor Marina Vamos - Director Liaison Psychiatry		Screencast
			mp4
	Bartter and Gitelman syndromes in adults: Diagnosis and management
	Capacity tool kit
	Capacity and the law ebook

Can chronic pain be cured?

	Laura Bruggink APA Pain Physiotherapist Dr Chris Hayes Director, Hunter Integrated Pain Service		Screencast
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	Leake HB, Moseley GL, Stanton TR, O'Hagan ET, Heathcote LC. What do patients value learning about pain? A mixed-methods survey on the relevance of target concepts after pain science education. Pain. 2021 Oct 1;162(10):2558-68. PubMed PMID: 33960326. eng.
	White R, Hayes C, White S, Hodson FJ. Using social media to challenge unwarranted clinical variation in the treatment of chronic noncancer pain: the "Brainman" story. J Pain Res. 2016;9:701-9. PubMed PMID: 27703395. PMCID: PMC5036613. Epub 20160922. eng.
	Tardif H, Hayes C, Allingham SF. Opioid cessation is associated with reduced pain and improved function in people attending specialist chronic pain services. Med J Aust. 2021 May;214(9):430-2. PubMed PMID: 33885163. Epub 20210422. eng.

Driving success in clinical trials

A panel discussion with independent clinical trial investigators
	Professor Jeanette Lechner-Scott Neurologist and leading clinical trialist in Multiple Sclerosis Dr Fiona Day Medical Oncologist, leading a trial in oesophageal cancer Prof Nikola Bowden Translation Cancer Researcher Professor Jenny Juhl Majersik Neurologist and Fullbright Scholar from Utah, developer of StrokeNet		Screencast
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	NIH StrokeNet
	Kashida YT, Garcia-Esperon C, Lillicrap T, Miteff F, Garcia-Bermejo P, Gangadharan S, et al. The Need for Structured Strategies to Improve Stroke Care in a Rural Telestroke Network in Northern New South Wales, Australia: An Observational Study. Front Neurol. 2021;12:645088. PubMed PMID: 33897601. PMCID: PMC8064411. Epub 20210409. eng.
	Achieving research in a clinical and health service setting: HNE Fellows learnings and reflections recording

NDIS and the hospital

	Dr David Kellett Staff Specialist, Rehabilitation Medicine Rankin Park Centre		Screencast
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Drugs with bite

	Dr Alison Chandler Haematology Advanced Trainee Calvary Mater Newcastle		Screencast
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	Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood. 2016 Jun 30;127(26):3321-30. PubMed PMID: 27207799. PMCID: PMC4929924. Epub 2016/05/22. eng
	Morris EC, Neelapu SS, Giavridis T, Sadelain M. Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy. Nat Rev Immunol. 2022 Feb;22(2):85-96. PubMed PMID: 34002066. PMCID: PMC8127450 application related to treatment of cytokine release syndrome: ‘Methods and compositions for alleviating cytokine release syndrome’ (WO2019099993A1). E.C.M. is scientific co-founder of Quell Therapeutics Ltd, which is developing chimeric antigen receptor (CAR)-modified regulatory T cells, and has served as a consultant to Kite, a Gilead company. S.S.N. served as consultant to Kite, a Gilead Company, Merck, Bristol-Myers Squibb, Novartis, Celgene, Pfizer, Allogene Therapeutics, Cell Medica/Kuur, Incyte, Precision Biosciences, Legend Biotech, Adicet Bio, Calibr and Unum Therapeutics; received research support from Kite, a Gilead Company, Bristol-Myers Squibb, Merck, Poseida, Cellectis, Celgene, Karus Therapeutics, Unum Therapeutics, Allogene Therapeutics, Precision Biosciences and Acerta; received royalties from Takeda Pharmaceuticals; and has intellectual property related to cell therapy. Epub 2021/05/19. eng.
	Santomasso B, Bachier C, Westin J, Rezvani K, Shpall EJ. The Other Side of CAR T-Cell Therapy: Cytokine Release Syndrome, Neurologic Toxicity, and Financial Burden. American Society of Clinical Oncology educational book American Society of Clinical Oncology Annual Meeting. 2019 Jan;39:433-44. PubMed PMID: 31099694. Epub 2019/05/18. eng.

Stroke care in 2022: Livening up the greyscale

	Dr Joe He Stroke Fellow Professor Neil Spratt Director, Acute Stroke Service & Co-Director, Department of Neurology		Screencast
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	Bivard A, Levi C, Lin L, Cheng X, Aviv R, Spratt NJ, et al. Assessing the Relative Value of CT Perfusion Compared to Non-contrast CT and CT Angiography in Prognosticating Reperfusion-Eligible Acute Ischemic Stroke Patients. Front Neurol. 2021;12:736768. PubMed PMID: 34566877. PMCID: PMC8458833. Epub 20210909. eng.
	Garcia-Esperon C, Soderhjelm Dinkelspiel F, Miteff F, Gangadharan S, Wellings T, B OB, et al. Implementation of multimodal computed tomography in a telestroke network: Five-year experience. CNS Neurosci Ther. 2020 Mar;26(3):367-73. PubMed PMID: 31568661. PMCID: PMC7052799. Epub 20190930. eng.

Update on donation and transplantation after circulatory death

	Dr Gerard Moynihan - Intensivist Nicole Coleman - CNC Donation Specialist Nurse Dr Ruth Hardstaff - General and Transplant Surgeon		Screencast
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	Cook DA, Widdicombe N. Audit of ten years of donation after circulatory death experience in Queensland: observations of agonal physiology following withdrawal of cardiorespiratory support. Anaesth Intensive Care. 2018 Jul;46(4):400-3. PubMed PMID: 29966114. eng.
	Walker W, Sque M. Family bereavement: A case study of controlled organ donation after circulatory death. Nurs Crit Care. 2019 Jul;24(4):229-34. PubMed PMID: 31144416. Epub 20190529. eng.
	Bastami S, Krones T, Biller-Andorno N. Relatives’ experiences of loved ones’ donation after circulatory and brain death. A qualitative inquiry. Donation after circulatory determination of death. Bioethica Forum. 2016; 9(1):17- 25
	Taylor LJ, Buffington A, Scalea JR, Fost N, Croes KD, Mezrich JD, et al. Harms of unsuccessful donation after circulatory death: An exploratory study. Am J Transplant. 2018 Feb;18(2):402-9. PubMed PMID: 28805291. PMCID: PMC5790593. Epub 20170918. eng.

COVID and autoimmunity: A claim for causality or casualty?

	Dr Dani Chandrasoma Dr Olav Tvedten Rheumatology Advanced Trainees		Screencast
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	Tang RSY, Kyaw MH, Teoh AYB, Lui RNS, Tse YK, Lam TYT, et al. Endoscopic ultrasound-guided cyanoacrylate injection to prevent rebleeding in hepatocellular carcinoma patients with variceal hemorrhage. J Gastroenterol Hepatol. 2020;35(12):2192-201.
	Fillon A, Sautenet B, Barbet C, Moret L, Thillard EM, Jonville-Béra AP, et al. De novo and relapsing necrotizing vasculitis after COVID-19 vaccination. Clin Kidney J. 2022 Mar;15(3):560-3. PubMed PMID: 35211310. PMCID: PMC8862065. Epub 20211220. eng.
	Shakoor MT, Birkenbach MP, Lynch M. ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis. 2021 Oct;78(4):611-3. PubMed PMID: 34280507. PMCID: PMC8285210. Epub 20210717. eng.
	Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol. 2018 Jun;15(6):586-94. PubMed PMID: 29503439. PMCID: PMC6078966. Epub 20180305. eng.
	Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021 Dec 17;24(12):103479. PubMed PMID: 34841223. PMCID: PMC8604799. Epub 20211120. eng.
	Pagnoux C, Mahr A, Cohen P, Guillevin L. Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated vasculitis. Medicine (Baltimore). 2005 Mar;84(2):115-28. PubMed PMID: 15758841. eng.
	Eriksson P, Segelmark M, Hallböök O. Frequency, Diagnosis, Treatment, and Outcome of Gastrointestinal Disease in Granulomatosis with Polyangiitis and Microscopic Polyangiitis. J Rheumatol. 2018 Apr;45(4):529-37. PubMed PMID: 29419474. Epub 20180201. eng.
	Murphy WJ, Longo DL. A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination. N Engl J Med. 2022 Jan 27;386(4):394-6. PubMed PMID: 34818473. Epub 20211124. eng.
	Connolly CM, Ruddy JA, Boyarsky BJ, Barbur I, Werbel WA, Geetha D, et al. Disease Flare and Reactogenicity in Patients With Rheumatic and Musculoskeletal Diseases Following Two-Dose SARS-CoV-2 Messenger RNA Vaccination. Arthritis Rheumatol. 2022 Jan;74(1):28-32. PubMed PMID: 34346185. PMCID: PMC8712346. Epub 20211203. eng.

To glue or not to glue? The sticky question

	Dr Yamini Yadav Gastroenterology Advanced Trainee Dr Stephen Bollipo Director, Gastroenterology		Screencast
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	Tang RSY, Kyaw MH, Teoh AYB, Lui RNS, Tse YK, Lam TYT, et al. Endoscopic ultrasound-guided cyanoacrylate injection to prevent rebleeding in hepatocellular carcinoma patients with variceal hemorrhage. J Gastroenterol Hepatol. 2020;35(12):2192-201.
	Philips CA, Ahamed R, Rajesh S, George T, Mohanan M, Augustine P. Beyond the scope and the glue: update on evaluation and management of gastric varices. BMC Gastroenterol. 2020;20(1):361.

Not for the faint hearted

	Dr Sarah Browning General Medicine Advanced Trainee Dr Alyssa Arnold General Respiratory & Sleep Physician John Hunter Hospital		Screencast
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	Mendu ML, McAvay G, Lampert R, Stoehr J, Tinetti ME. Yield of diagnostic tests in evaluating syncopal episodes in older patients. Arch Intern Med. 2009 Jul 27;169(14):1299-305. PubMed PMID: 19636031. PMCID: PMC3752785. Epub 2009/07/29. eng.
	Prandoni P, Milan M, Sarolo L, Zanon E, Bilora F. Optimal duration of anticoagulation in patients with unprovoked venous thromboembolism: the impact of novel anticoagulants. Int Angiol. 2017 Oct;36(5):395-401. PubMed PMID: 27982558. Epub 2016/12/17. eng.
	Badertscher P, du Fay de Lavallaz J, Hammerer-Lercher A, Nestelberger T, Zimmermann T, Geiger M, et al. Prevalence of Pulmonary Embolism in Patients With Syncope. J Am Coll Cardiol. 2019 Aug 13;74(6):744-54. PubMed PMID: 31395124. Epub 2019/08/10. eng.
	Costantino G, Ruwald MH, Quinn J, Camargo CA, Jr., Dalgaard F, Gislason G, et al. Prevalence of Pulmonary Embolism in Patients With Syncope. JAMA internal medicine. 2018 Mar 1;178(3):356-62. PubMed PMID: 29379959. PMCID: PMC5885902 R01HL111033 from the National Institutes of Health (NIH) and serving as a consultant for Medtronic. No other disclosures were reported. Epub 2018/01/31. eng.
	Raynal PA, Cachanado M, Truchot J, Damas-Perrichet C, Feral-Pierssens AL, Goulet H, et al. Prevalence of pulmonary embolism in emergency department patients with isolated syncope: a prospective cohort study. Eur J Emerg Med. 2019 Dec;26(6):458-61. PubMed PMID: 31609876. Epub 2019/10/15. eng.
	de Winter MA, van Bergen EDP, Welsing PMJ, Kraaijeveld AO, Kaasjager K, Nijkeuter M. The Prognostic Value of Syncope on Mortality in Patients With Pulmonary Embolism: A Systematic Review and Meta-analysis. Ann Emerg Med. 2020 Oct;76(4):527-41. PubMed PMID: 32461009. Epub 2020/05/29. eng.

End of life law for clinicians

	Guest speaker: Professor Ben White Professor of End-of-Life Law and Regulation Australian Research Council Future Fellow (Professorial level, 2020-2024) Australian Centre for Health Law Research at the Faculty of Business & Law Queensland University of Technology		Screencast
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			Chat transcript
	Jeanette Lacey End of Life Care Nurse Practitioner Palliative and End of Life Care Medical and Interventional Services John Hunter Hospital
	End of Life Law for Clinicians (ELLC) is a free training program for medical practitioners, medical students, nurses, and allied and other health professionals about the law relating to end of life decision-making. Improving your knowledge of end of life law can enhance your capacity to manage legal issues in end of life decision-making, leading to improved quality of care and practice. Register here
	Capacity and consent
	Treatment decisions
	Advanced care directives in NSW
	Advanced care directives common law
	Hunter and New England Area Health Service v A [2009] NSWSC 761
	Isaac Messiha (by his tutor Magdy Messiha) v South East Health [2004] NSWSC 1061
	Northridge v Central Sydney Area Health Service [2000] NSWSC 1241 revised - 17/01/2001
	NSW Health Consent to Medical and Healthcare Treatment Manual
	White B, Willmott L, Trowse P, Parker M, Cartwright C. The legal role of medical professionals in decisions to withhold or withdraw life-sustaining treatment: part 1 (New South Wales). J Law Med. 2011;18(3):498-522.
	HNELHD Clinical Guideline, Advance Care Directives – Adult HNELHD CG 20_06
	NSW Ministry of Health Policy Directive, Using Resuscitation Plans in End of Life Decisions PD2014_030
	HNELHD Policy Compliance Procedure, Completing the Adult Resuscitation Plans in End of Life Decisions PD2014_030:PCP 1

Malignant pleural effusions

	Dr Vineeth George Staff Specialist, Respiratory and Sleep Medicine John Hunter Hospital		Screencast
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	Arnold DT, De Fonseka D, Perry S, Morley A, Harvey JE, Medford A, et al. Investigating unilateral pleural effusions: the role of cytology. Eur Respir J. 2018 Nov;52(5). PubMed PMID: 30262573. Epub 2018/09/29. eng.
	Mercer RM, Varatharajah R, Shepherd G, Lu Q, Castro-Añón O, McCracken DJ, et al. Critical analysis of the utility of initial pleural aspiration in the diagnosis and management of suspected malignant pleural effusion. BMJ open respiratory research. 2020 Sep;7(1). PubMed PMID: 32963027. PMCID: PMC7509958. Epub 2020/09/24. eng.
	Hallifax RJ, Haris M, Corcoran JP, Leyakathalikhan S, Brown E, Srikantharaja D, et al. Role of CT in assessing pleural malignancy prior to thoracoscopy. Thorax. 2015 Feb;70(2):192-3. PubMed PMID: 25077699. Epub 2014/08/01. eng.
	Muruganandan S, Azzopardi M, Thomas R, Fitzgerald DB, Kuok YJ, Cheah HM, et al. The Pleural Effusion And Symptom Evaluation (PLEASE) study of breathlessness in patients with a symptomatic pleural effusion. Eur Respir J. 2020 May;55(5). PubMed PMID: 32079642. Epub 20200514. eng.
	Bhatnagar R, Piotrowska HEG, Laskawiec-Szkonter M, Kahan BC, Luengo-Fernandez R, Pepperell JCT, et al. Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial. JAMA. 2020 Jan 7;323(1):60-9. PubMed PMID: 31804680. PMCID: PMC6990658. eng.
	Davies HE, Mishra EK, Kahan BC, Wrightson JM, Stanton AE, Guhan A, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial. JAMA. 2012 Jun 13;307(22):2383-9. PubMed PMID: 22610520. eng.

Kidney health for all

	Dr Matthew Rowlandson Staff Specialist, Nephrology John Hunter Hospital		Screencast
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	Malhotra R, Nguyen HA, Benavente O, Mete M, Howard BV, Mant J, et al. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA internal medicine. 2017 Oct 1;177(10):1498-505. PubMed PMID: 28873137. PMCID: PMC5704908. Epub 2017/09/06. eng
	Neuen BL, Young T, Heerspink HJL, Neal B, Perkovic V, Billot L, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. The lancet Diabetes & endocrinology. 2019 Nov;7(11):845-54. PubMed PMID: 31495651. Epub 2019/09/10. eng.
	Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019 Jun 13;380(24):2295-306. PubMed PMID: 30990260. Epub 2019/04/17. eng.
	Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020 Oct 8;383(15):1436-46. PubMed PMID: 32970396. Epub 2020/09/25. eng.

Perioperative anaemia

	Dr Gabrielle Papiex Anaesthetist John Hunter Hospital		Screencast
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	Patient Blood Management Guidelines: Module 2 Perioperative

Is the hospital autopsy dead and buried?

	Dr Mark Formby Divisional Director & Senior Staff Specialist, Anatomical Pathology John Hunter Hospital		Screencast
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	Marshall HS, Milikowski C. Comparison of Clinical Diagnoses and Autopsy Findings: Six-Year Retrospective Study. Arch Pathol Lab Med. 2017 Sep;141(9):1262-6. PubMed PMID: 28657772. Epub 2017/06/29. eng.

Update on COVID-19: 2 cases and an update on epidemiology and treatment

	Dr Joann Pinto & Dr Victoria Jordan Advanced Trainees, Infectious Diseases Professor David Durrheim HNELHD Population Health Professor Josh Davis Deputy Director, Immunology and Infectious Diseases		Screencast
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	National COVID-19 Evidence Taskforce
	HNELHD COVID-19 guidelines
	Machado M, Valerio M, Álvarez-Uría A, Olmedo M, Veintimilla C, Padilla B, et al. Invasive pulmonary aspergillosis in the COVID-19 era: An expected new entity. Mycoses. 2021 Feb;64(2):132-43. PubMed PMID: 33210776. PMCID: PMC7753705. Epub 20201129. eng.
	Arastehfar A, Carvalho A, van de Veerdonk FL, Jenks JD, Koehler P, Krause R, et al. COVID-19 Associated Pulmonary Aspergillosis (CAPA)-From Immunology to Treatment. J Fungi (Basel). 2020 Jun 24;6(2). PubMed PMID: 32599813. PMCID: PMC7346000. Epub 20200624. eng.
	Salmanton-García J, Sprute R, Stemler J, Bartoletti M, Dupont D, Valerio M, et al. COVID-19-Associated Pulmonary Aspergillosis, March-August 2020. Emerg Infect Dis. 2021;27(4):1077-86. PubMed PMID: 33539721. PMCID: PMC8007287. Epub 20210204. eng.
	Lai CC, Yu WL. COVID-19 associated with pulmonary aspergillosis: A literature review. J Microbiol Immunol Infect. 2021 Feb;54(1):46-53. PubMed PMID: 33012653. PMCID: PMC7513876. Epub 20200924. eng.
	Permpalung N, Chiang TP, Massie AB, Zhang SX, Avery RK, Nematollahi S, et al. Coronavirus Disease 2019-Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients. Clin Infect Dis. 2022 Jan 7;74(1):83-91. PubMed PMID: 33693551. PMCID: PMC7989534. eng.
	Martin A, Otto T, Smith T. A Case of COVID-19 Mimicking Acute Appendicitis in Multi-System Inflammatory Syndrome. Cureus. 2021 Jun;13(6):e15600. PubMed PMID: 34277221. PMCID: PMC8272943. Epub 20210611. eng.
	Malbul K, Katwal S, Maharjan S, Shrestha S, Dhital R, Rajbhandari AP. Appendicitis as a presentation of COVID-19: A case report. Ann Med Surg (Lond). 2021 Sep;69:102719. PubMed PMID: 34422263. PMCID: PMC8372448. Epub 20210818. eng.
	1. Jayk Bernal A, Gomes da Silva MM, Musungaie DB, Kovalchuk E, Gonzalez A, Delos Reyes V, et al. Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients. N Engl J Med. 2022 Feb 10;386(6):509-20. PubMed PMID: 34914868. PMCID: PMC8693688. Epub 20211216. eng.
	Gottlieb RL, Vaca CE, Paredes R, Mera J, Webb BJ, Perez G, et al. Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients. N Engl J Med. 2022 Jan 27;386(4):305-15. PubMed PMID: 34937145. PMCID: PMC8757570. Epub 20211222. eng.

A hypercalcaemic conundrum

	Dr Jasmine Wintour Advanced Trainee, Endocrinology John Hunter Hospital		Screencast
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	Neonatal hypocalcemia

Ablation for atrial fibrillation

	Dr Nick Jackson Staff Specialist, Cardiology Dr Gwilym Morris Staff Specialist, Cardiology and Electrophysiology British Heart Foundation Intermediate Research Fellow, University of Manchester		Screencast
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	Lane DA, Skjøth F, Lip GYH, Larsen TB, Kotecha D. Temporal Trends in Incidence, Prevalence, and Mortality of Atrial Fibrillation in Primary Care. JAHA. 2017 Apr 28;6(5). PubMed PMID: 28455344. PMCID: PMC5524079. Epub 2017/04/30. eng.
	Chang ET, Lin YT, Galla T, Clayton RH, Eatock J. A Stochastic Individual-Based Model of the Progression of Atrial Fibrillation in Individuals and Populations. PLoS One. 2016;11(4):e0152349. PubMed PMID: 27070920. PMCID: PMC4829251. Epub 2016/04/14. eng.
	Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, et al. Catheter Ablation for Atrial Fibrillation with Heart Failure. N Engl J Med. 2018 Feb 1;378(5):417-27. PubMed PMID: 29385358. Epub 2018/02/01. eng.
	Cheniti G, Vlachos K, Pambrun T, Hooks D, Frontera A, Takigawa M, et al. Atrial Fibrillation Mechanisms and Implications for Catheter Ablation. Front Physiol. 2018;9:1458. PubMed PMID: 30459630. PMCID: PMC6232922. Epub 2018/11/22. eng.
	Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998 Sep 3;339(10):659-66. PubMed PMID: 9725923. Epub 1998/09/03. eng.
	Ganesan AN, Shipp NJ, Brooks AG, Kuklik P, Lau DH, Lim HS, et al. Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis. JAHA. 2013 Mar 18;2(2):e004549. PubMed PMID: 23537812. PMCID: PMC3647286. Epub 2013/03/30. eng.
	Verma A, Jiang CY, Betts TR, Chen J, Deisenhofer I, Mantovan R, et al. Approaches to catheter ablation for persistent atrial fibrillation. N Engl J Med. 2015 May 7;372(19):1812-22. PubMed PMID: 25946280. Epub 2015/05/07. eng.

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This page was last updated on 10 January 2023