2022

Previous years 2021 2020

Tuesdays, 12.30 pm - 1.30 pm, RNC Lecture Theatre

15 Nov	Fluid therapy in sepsis: The great 20 ml/kg hoax?
	Associate Professor Koert de Waal Paediatric Neonatologist John Hunter Children's Hospital	Screencast
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	Septic shock in children: Rapid recognition and initial resuscitation (first hour)
	Steurer MA, Jelliffe-Pawlowski LL, Baer RJ, Partridge JC, Rogers EE, Keller RL. Persistent Pulmonary Hypertension of the Newborn in Late Preterm and Term Infants in California. Pediatrics. 2017 Jan;139(1). PubMed PMID: 27940508. Epub 20161201. eng.
	Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-247. PubMed PMID: 34599691. PMCID: PMC8486643. Epub 20211002. eng.
	Bakker J, Kattan E, Annane D, Castro R, Cecconi M, De Backer D, et al. Current practice and evolving concepts in septic shock resuscitation. Intensive Care Med. 2022 Feb;48(2):148-63. PubMed PMID: 34910228. Epub 20211215. eng.

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Respiratory disease in early life: The common, the complex and the mixed

What's new in ADHD?

Back from the dead

Cerebral Palsy: Early Diagnosis Clinic

Paediatric IBD: What's new and how we do it

ED pot pourri

Bringing order to disorded eating: Improving patient care

Realistic expectations: Why weight loss is not always the goal

When smoke gets in your lungs

Deadly hearts: ARF and RHD in 2022

Improving function for children and young people with cerebral palsy

The vital TREC with tiny feet

Toxicology through the ages

Keep calm and call a nurse

Whole exome sequqncing and beyond

Bushfire smoke is associated with Forced Vital Capacity decrease in asthmatic children

Epilepsy awareness

Understanding and deconstructing hypoxia

Omicron: Lessons learnt this summer

	Dr Joerg Mattes Paediatric Respiratory and Sleep Medicine Specialist Dr Adam Collison, PhD		Screencast
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	University of Newcastle Priority Research Centre for Grow Up Well
	Congenital diaphragmatic hernia in the neonate
	Leeuwen L, Fitzgerald DA. Congenital diaphragmatic hernia. J Paediatr Child Health. 2014 Sep;50(9):667-73. PubMed PMID: 24528549. Epub 20140217. eng.
	Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, et al. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. N Engl J Med. 2018 Mar 22;378(12):1121-31. PubMed PMID: 29562151. eng.
	Powell H, Murphy VE, Taylor DR, Hensley MJ, McCaffery K, Giles W, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011 Sep 10;378(9795):983-90. PubMed PMID: 21907861. eng.
	Morten M, Collison A, Murphy VE, Barker D, Oldmeadow C, Attia J, et al. Managing Asthma in Pregnancy (MAP) trial: FENO levels and childhood asthma. J Allergy Clin Immunol. 2018 Dec;142(6):1765-72.e4. PubMed PMID: 29524536. Epub 20180308. eng.
	de Gouveia Belinelo P, Collison AM, Murphy VE, Robinson PD, Jesson K, Hardaker K, et al. Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts. Thorax. 2021 Oct;76(10):996-1001. PubMed PMID: 33632766. Epub 20210225. eng.
	Kepreotes E, Whitehead B, Attia J, Oldmeadow C, Collison A, Searles A, et al. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. Lancet. 2017 Mar 4;389(10072):930-9. PubMed PMID: 28161016. Epub 20170202. eng.

	Dr Sarahn Lovett Clinical Lead, ADHD Shared Care HNE Kids		Screencast
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	Attention deficit hyperactivity disorder in children and adolescents: Overview of treatment and prognosis
	Australian Evidence-Based Clinical Guideline For ADHD
	Deloitte Access Economics. The social and economic costs of ADHD in Australia $20 billion: the high cost of ADHD. Report prepared for the Australian ADHD Professionals Association, 2019
	Attention Deficit Hyperactivity Disorder (ADHD)

	Dr Nagaraj Pandharikar Paediatric cardiologist John Hunter Children's Hospital		Screencast
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	Sudden cardiac arrest and death in children
	Shimoda-Sakano TM, Schvartsman C, Reis AG. Epidemiology of pediatric cardiopulmonary resuscitation. Jornal de pediatria. 2020 Jul-Aug;96(4):409-21. PubMed PMID: 31580845. PMCID: PMC9432320. Epub 20190930. eng.
	Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. Circulation. 2020 Mar 3;141(9):e139-e596. PubMed PMID: 31992061. Epub 20200129. eng.
	Slomine BS, Silverstein FS, Christensen JR, Page K, Holubkov R, Dean JM, et al. Neuropsychological Outcomes of Children 1 Year After Pediatric Cardiac Arrest: Secondary Analysis of 2 Randomized Clinical Trials. JAMA Neurol. 2018 Dec 1;75(12):1502-10. PubMed PMID: 30242322. PMCID: PMC6583192. eng.

	Aimee Martin Manager, Therapy Services Cerebral Palsy Alliance		Screencast
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	Cerebral palsy: Evaluation and diagnosis
	Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom-Hernandez J, et al. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment. JAMA Pediatr. 2017;171(9):897-907.
	Morgan C, Fetters L, Adde L, Badawi N, Bancale A, Boyd RN, et al. Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy: International Clinical Practice Guideline Based on Systematic Reviews. JAMA Pediatr. 2021;175(8):846-58.
	Te Velde A, Tantsis E, Novak I, Badawi N, Berry J, Golland P, et al. Age of Diagnosis, Fidelity and Acceptability of an Early Diagnosis Clinic for Cerebral Palsy: A Single Site Implementation Study. Brain Sci. 2021;11(8).
	Maitre NL, Burton VJ, Duncan AF, Iyer S, Ostrander B, Winter S, et al. Network Implementation of Guideline for Early Detection Decreases Age at Cerebral Palsy Diagnosis. Pediatrics. 2020;145(5).

Presented by the Paediatric Gastroenterology Team
	Dr Li-Zsa Tan - Staff Specialist Dr Scott Nightingale - Staff Specialist Kathryn Jesson - Nurse Michelle Cooper - Nurse Erin Koen - Social Worker Deidre Burgess - Dietician	Screencast
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	Clinical presentation and diagnosis of inflammatory bowel disease in children
	Chang JT. Pathophysiology of Inflammatory Bowel Diseases. N Engl J Med. 2020 Dec 31;383(27):2652-64. PubMed PMID: 33382932. eng.
	Lackner JM, Gudleski GD, Thakur ER, Stewart TJ, Iacobucci GJ, Spiegel BM. The impact of physical complaints, social environment, and psychological functioning on IBS patients' health perceptions: looking beyond GI symptom severity. Am J Gastroenterol. 2014 Feb;109(2):224-33. PubMed PMID: 24419481. PMCID: PMC5039032. Epub 20140114. eng.
	Burgess D, McGrath KH, Watson C, Collins T, Brown S, Marks K, et al. Exclusive enteral nutrition: An optimal care pathway for use in children with active luminal Crohn's disease. J Paediatr Child Health. 2022 Apr;58(4):572-8. PubMed PMID: 35181966. Epub 20220218. eng.

hne health libraries linking evidence with practice

2022

Quick links

Education

Presented by the Paediatric ED Team
	Assessment Plus - Dr Rob Feltrin & Ms Loren Kirkpatrick CUSTARD project - Dr Michael Zhang HNE Virtual Kids - Dr Coen Butters, Ms Julie Evans, Ms Telesia Taufa'Ao	Screencast
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	Eating disorders: Overview of prevention and treatment
	Local Procedure. John Hunter Emergency Department: Assessment Plus. JHH_0437: ED Assessment Plus
	Biagi C, Pierantoni L, Baldazzi M, Greco L, Dormi A, Dondi A, et al. Lung ultrasound for the diagnosis of pneumonia in children with acute bronchiolitis. BMC Pulm Med. 2018 Dec 7;18(1):191. PubMed PMID: 30526548. PMCID: PMC6286612. Epub 20181207. eng.
	Hegazy LM, Rezk AR, Sakr HM, Ahmed AS. Comparison of Efficacy of LUS and CXR in the Diagnosis of Children Presenting with Respiratory Distress to Emergency Department. Indian J Crit Care Med. 2020 Jun;24(6):459-64. PubMed PMID: 32863640. PMCID: PMC7435092. eng.
	Hendaus MA, Jomha FA, Alhammadi AH. Lung ultrasound for the diagnosis of childhood pneumonia: a safe and accurate imaging mode. Ther Clin Risk Manag. 2015;11:1817-8. PubMed PMID: 26677334. PMCID: PMC4677756. Epub 20151209. eng.
	Ianniello S, Piccolo CL, Buquicchio GL, Trinci M, Miele V. First-line diagnosis of paediatric pneumonia in emergency: lung ultrasound (LUS) in addition to chest-X-ray (CXR) and its role in follow-up. Br J Radiol. 2016;89(1061):20150998. PubMed PMID: 26689098. PMCID: PMC4985480. Epub 20160122. eng.
	Orso D, Ban A, Guglielmo N. Lung ultrasound in diagnosing pneumonia in childhood: a systematic review and meta-analysis. J Ultrasound. 2018 Sep;21(3):183-95. PubMed PMID: 29931473. PMCID: PMC6113181. Epub 20180621. eng.
	Yan C, Hui R, Lijuan Z, Zhou Y. Lung ultrasound vs. chest X-ray in children with suspected pneumonia confirmed by chest computed tomography: A retrospective cohort study. Exp Ther Med. 2020 Feb;19(2):1363-9. PubMed PMID: 32010310. PMCID: PMC6966229. Epub 20191216. eng.

Presented by the Paediatric Nurse Educator Team
	Tegan Izzard Ellen Mills	Screencast
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	Eating disorders: Overview of prevention and treatment
	Local Guideline. Eating Disorders in Paediatrics: Inpatient Management. JHCH 4.4

Presented by the Weight Management Team
	Dr Liz Percival - Staff Specialist General Paediatrician Ms Meredith Jordan - Paediatric Clinical Psychologist	Screencast
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	Cohen J, Alexander S, Critekos M, Garnett SP, Hayes AJ, Shaw T, et al. The acceptability, effectiveness, and impact of different models of care for pediatric weight management services: protocol for a concurrent mixed-methods study. BMC Health Serv Res. 2018 Jun 7;18(1):417. PubMed PMID: 29879963. PMCID: PMC5992636. Epub 2018/06/09. eng
	Tylka TL, Annunziato RA, Burgard D, Daníelsdóttir S, Shuman E, Davis C, et al. The weight-inclusive versus weight-normative approach to health: evaluating the evidence for prioritizing well-being over weight loss. J Obes. 2014;2014:983495. PubMed PMID: 25147734. PMCID: PMC4132299. Epub 2014/08/26. eng.

	Dr Cristina Arombo Paediatric Registrar Tamworth Hospital		Screencast
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	Granulomatosis with polyangiitis and microscopic polyangiitis: Respiratory tract involvement
	E-cigarette or vaping product use-associated lung injury (EVALI)
	Markland A, Hansen G, Banks A, Chibbar R, Adamko D. A Pediatric Case of Diffuse Alveolar Hemorrhage Secondary to Poststreptococcal Glomerulonephritis. Case Rep Crit Care. 2017;2017:1050284. PubMed PMID: 29423322. PMCID: PMC5750514. Epub 20171220. eng.
	Thangaraj Y, Ather I, Chataut H, Ayach T, Holtzman A, Wakefield D, et al. Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis. Am J Med. 2014 Sep;127(9):e15-7. PubMed PMID: 24927907. Epub 20140610. eng.
	Miech RA, Patrick ME, O'Malley PM, Johnston LD, Bachman JG. Trends in Reported Marijuana Vaping Among US Adolescents, 2017-2019. JAMA. 2020 Feb 4;323(5):475-6. PubMed PMID: 31848566. PMCID: PMC6990699. eng.
	Chand HS, Muthumalage T, Maziak W, Rahman I. Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury. Front Pharmacol. 2019;10:1619. PubMed PMID: 31992985. PMCID: PMC6971159. Epub 20200114. eng.
	Rao DR, Maple KL, Dettori A, Afolabi F, Francis JKR, Artunduaga M, et al. Clinical Features of E-cigarette, or Vaping, Product Use-Associated Lung Injury in Teenagers. Pediatrics. 2020 Jul;146(1). PubMed PMID: 32393606. PMCID: PMC7961805. Epub 20200511. eng.
	SCHN, Vaping is not cool, presented by Professor Adam Jaffe, Respiratory Paediatrician. March 2022

	Dr Jascha Kehr Paediatric Cardiologist		Screencast
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	Clinical manifestations and diagnosis of rheumatic heart disease
	ARF RHD Guideline. The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease (3.2 edition, March 2022)
	Hunter New England Community Health Pathways, Acute Rheumatic Disease
	Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1789-858. PubMed PMID: 30496104. PMCID: PMC6227754. Epub 20181108. eng.
	Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. PubMed PMID: 33309175. PMCID: PMC7755038. eng.
	Katzenellenbogen JM, Bond-Smith D, Seth RJ, Dempsey K, Cannon J, Stacey I, et al. Contemporary Incidence and Prevalence of Rheumatic Fever and Rheumatic Heart Disease in Australia Using Linked Data: The Case for Policy Change. J Am Heart Assoc. 2020 Oct 20;9(19):e016851. PubMed PMID: 32924748. PMCID: PMC7792417. Epub 20200914. eng.
	Rafeek RAM, Lobbe CM, Wilkinson EC, Hamlin AS, Andronicos NM, McMillan DJ, et al. Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post-streptococcal autoimmune sequelae. Animal Model Exp Med. 2021 Jun;4(2):151-61. PubMed PMID: 34179722. PMCID: PMC8212825. Epub 20210408. eng.
	Ralph AP, Webb R, Moreland NJ, McGregor R, Bosco A, Broadhurst D, et al. Searching for a technology-driven acute rheumatic fever test: the START study protocol. BMJ Open. 2021 Sep 15;11(9):e053720. PubMed PMID: 34526345. PMCID: PMC8444258. Epub 20210915. eng.
	Culliford-Semmens N, Tilton E, Wilson N, Stirling J, Doughty R, Gentles T, et al. Echocardiography for latent rheumatic heart disease in first degree relatives of children with acute rheumatic fever: Implications for active case finding in family members. EClinicalMedicine. 2021 Jul;37:100935. PubMed PMID: 34386737. PMCID: PMC8343257. Epub 20210604. eng.
	Beaton A, Okello E, Rwebembera J, Grobler A, Engelman D, Alepere J, et al. Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease. N Engl J Med. 2022 Jan 20;386(3):230-40. PubMed PMID: 34767321. Epub 20211113. eng.
	Osowicki J, Azzopardi KI, Fabri L, Frost HR, Rivera-Hernandez T, Neeland MR, et al. A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study. Lancet Microbe. 2021 Jul;2(7):e291-e9. PubMed PMID: 35544165. Epub 20210415. eng.
	Francis JR, Fairhurst H, Whalley G, Kaethner A, Ralph A, Yan J, et al. The RECARDINA Study protocol: diagnostic utility of ultra-abbreviated echocardiographic protocol for handheld machines used by non-experts to detect rheumatic heart disease. BMJ Open. 2020 May 27;10(5):e037609. PubMed PMID: 32467256. PMCID: PMC7259846. Epub 20200527. eng.

Presented by the Paediatric Occupational Therapy Team
	Dr Michelle Jackman Paediatric Occupational Therapist John Hunter Children's Hospital	Screencast
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	Cerebral palsy: Overview of management and prognosis
	Jackman M, Sakzewski L, Morgan C, Boyd RN, Brennan SE, Langdon K, et al. Interventions to improve physical function for children and young people with cerebral palsy: international clinical practice guideline. Dev Med Child Neurol. 2022 May;64(5):536-49. PubMed PMID: 34549424. Epub 20210921. eng.
	Tasker RC, Acerini CL, Holloway E, Shah A, Lillitos P, editors. Oxford Handbook of Paediatrics. Oxford: Oxford University Press, Incorporated; 2021.

Presented by the Paediatric Allergy and Immunology Team
	Dr Kahn Preece - Paediatric Immunologist Jessica Archer - Paediatric Immunology Registrar Kirrilly Mills - Parent of Henry Mills	Screencast
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	Wekell P, Hertting O, Holmgren D, Fasth A. An overview of how on-call consultant paediatricians can recognise and manage severe primary immunodeficiencies. Acta Paediatr. 2019 Dec;108(12):2175-85. PubMed PMID: 31278775. Epub 20190823. eng.
	Richards S, Gennery AR, Davies EG, Wong M, Shaw PJ, Peake J, et al. Diagnosis and management of severe combined immunodeficiency in Australia and New Zealand. J Paediatr Child Health. 2020 Oct;56(10):1508-13. PubMed PMID: 33099818. eng.
	Reeve L, Preece K, Markle J, Casanova JL, Walls T. Do not let them slip through the net: Catching a case of leaky severe combined immunodeficiency. J Paediatr Child Health. 2020 May;56(5):809-11. PubMed PMID: 31721334. Epub 20191113. eng.
	Biggs CM, Haddad E, Issekutz TB, Roifman CM, Turvey SE. Newborn screening for severe combined immunodeficiency: a primer for clinicians. CMAJ. 2017 Dec 18;189(50):E1551-e7. PubMed PMID: 29255099. PMCID: PMC5738248. eng.
	Kohn DB, Hershfield MS, Puck JM, Aiuti A, Blincoe A, Gaspar HB, et al. Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. J Allergy Clin Immunol. 2019 Mar;143(3):852-63. PubMed PMID: 30194989. PMCID: PMC6688493. Epub 20180905. eng.

Presented by the PICU SS group
	Dr Gerard Moynihan - Staff Specialist Dr Yolanda Coleman - Paediatric Intensive Care Staff Specialist Lee Tam Teo - Paediatric Intensive Care Staff Specialist Rajshree Trivedi - Paediatric Intensive Care Staff Specialist	Screencast
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	Clinical manifestations and diagnosis of acetaminophen (paracetamol) poisoning in children and adolescents
	Inhalant abuse in children and adolescents

	Transition Angie Myles - Transition Care Co-ordinator, Northern/ ACI Transition Care Network 2 roles, 2 hats: POPD & cleft palate Bronwyn McKinley - Clinical Co-ordinator Criteria for discharge Madhuri Jain - General Paediatric Fellow Complex paediatric care: It's a team sport Jared Allen - General Paediatrics CNC		Screencast
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	Key Principles for Transition of Young People from Paediatric to Adult Health Care

Presented by Hunter Genetics
	Dr Anne Baxter - Geneticist Dr Anna Hau - Paediatric Registrar & Hunter Genetics Fellow	Screencast
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	Stark Z, Tan TY, Chong B, Brett GR, Yap P, Walsh M, et al. A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders. Genet Med. 2016 Nov;18(11):1090-6. PubMed PMID: 26938784. Epub 20160303. eng.
	Shah M, Selvanathan A, Baynam G, Berman Y, Boughtwood T, Freckmann ML, et al. Paediatric genomic testing: Navigating genomic reports for the general paediatrician. J Paediatr Child Health. 2022 Jan;58(1):8-15. PubMed PMID: 34427008. Epub 20210823. eng.

Presented by HMRI
	Dr Carla Sena Post Doctoral Researcher HMRI	Screencast
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Presented by the Paediatric Neurology Team
	Janis Brown - CNC Dr Rob Smith - Paediatric Neurologist Dr Christina Miteff - Paediatric Neurologist Meredith Jordan - Clinical Psychologist With guest presenter Melissa Jovanovic - Leader Psychological Practice, NSW Department of Education	Screencast
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	Aaberg KM, Bakken IJ, Lossius MI, Lund Søraas C, Håberg SE, Stoltenberg C, et al. Comorbidity and Childhood Epilepsy: A Nationwide Registry Study. Pediatrics. 2016 Sep;138(3). PubMed PMID: 27482059. Epub 2016/08/03. eng.

Understanding and deconstructing hypoxia: Defining persistent pulmonary hypertension of the newborn (PPHN)
	Assoc Prof Koert de Waal Staff Specialist, NICU John Hunter Children's Hospital	Screencast
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	Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, et al. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021 Sep 4;398(10303):843-55. PubMed PMID: 34388395. PMCID: PMC8354567
	Noori S, Wlodaver A, Gottipati V, McCoy M, Schultz D, Escobedo M. Transitional changes in cardiac and cerebral hemodynamics in term neonates at birth. J Pediatr. 2012 Jun;160(6):943-8. PubMed PMID: 22244465. Epub 2012/01/17. eng.
	Muniraman HK, Song AY, Ramanathan R, Fletcher KL, Kibe R, Ding L, et al. Evaluation of Oxygen Saturation Index Compared With Oxygenation Index in Neonates With Hypoxemic Respiratory Failure. JAMA network open. 2019 Mar 1;2(3):e191179. PubMed PMID: 30924897. PMCID: PMC6450323. Epub 2019/03/30. eng.
	de Waal K, Kluckow M. Prolonged rupture of membranes and pulmonary hypoplasia in very preterm infants: pathophysiology and guided treatment. J Pediatr. 2015 May;166(5):1113-20. PubMed PMID: 25681201. Epub 2015/02/15. eng.
	Lapointe A, Barrington KJ. Pulmonary hypertension and the asphyxiated newborn. J Pediatr. 2011 Feb;158(2 Suppl):e19-24. PubMed PMID: 21238701. Epub 2011/02/02. eng.

	Dr Kevin Jones Dr Coen Butters - Infectious Diseases Physician Dr Kate Thomson Bowe - Deputy Director, Paediatrics Dr Brooke Gardiner - Paediatric Oncology SRMO A/Prof Rani Bhatia -Paediatric Allergist & Immunologist		Screencast
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	Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, et al. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021 Sep 4;398(10303):843-55. PubMed PMID: 34388395. PMCID: PMC8354567
	Gupta A, Gonzalez-Rojas Y, Juarez E, Crespo Casal M, Moya J, Falci DR, et al. Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab. N Engl J Med. 2021 Nov 18;385(21):1941-50. PubMed PMID: 34706189. Epub 2021/10/28. eng.
	Gottlieb RL, Vaca CE, Paredes R, Mera J, Webb BJ, Perez G, et al. Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients. N Engl J Med. 2022 Jan 27;386(4):305-15. PubMed PMID: 34937145. PMCID: PMC8757570. Epub 2021/12/23. eng.
	Heil EL, Kottilil S. The Goldilocks Time for Remdesivir - Is Any Indication Just Right? N Engl J Med. 2022 Jan 27;386(4):385-7. PubMed PMID: 34936760. PMCID: PMC8757566. Epub 2021/12/23. eng.
	Lee TC, Morris AM, Grover SA, Murthy S, McDonald EG. Outpatient Therapies for COVID-19: How Do We Choose? Open Forum Infectious Diseases. 2022;9(3).
	Torjesen I. Covid-19: Omicron variant is linked to steep rise in hospital admissions of very young children. BMJ. 2022 Jan 14;376:o110. PubMed PMID: 35031537. Epub 2022/01/16. eng.